Ms. Letlow, who lives in Richland Parish, currently serves as the director of external relations and strategic communications at the University of Louisiana in Monroe.
Her entrance into the nonpartisan election on March 20 was widely anticipated and may discourage other Republicans who had been mulling a run from entering the race.
She is likely to face Allen Guillory Sr., a Republican from Opelousas, who tallied under 10 percent in the Nov. 3 election, and Sandra “Candy” Christophe, a Democrat from Alexandria who announced last week she would run.
Ms. Letlow has been active in Louisiana Republican politics for years and was selected for her university job, in part, to provide “insight into strategies and alliances” that would be helpful for the school during its interactions with elected officials, her online biography said.
“I am running to continue the mission Luke started — to stand up for our Christian values, to fight for our rural agricultural communities and to deliver real results to move our state forward,” she said in her statement.